The Soboleva group delves into the intricate interplay of epigenetics, cell differentiation, and cancer, investigating how epigenetic mechanisms orchestrate gene expression to maintain cellular identity while enabling adaptation to environmental changes. Their research focuses on understanding the role of epigenetic regulators in spermatogenesis and their implications in cancer, particularly emphasizing the histone variant H2A.B. This variant not only facilitates transcription by opening chromatin but also engages directly with RNA, influencing pre-mRNA splicing—a groundbreaking discovery that expands our understanding of epigenetic regulation. Through collaborative efforts, they aim to uncover novel mechanisms of epigenetic control coordinated by H2A.B, offering transformative insights into developmental biology and cancer biology alike.