Australian National University
Prof.
David Tremethick
Investigating histone variants in gene regulation and chromatin architecture, with a focus on their roles in development, pre-mRNA splicing, brain function, and cancer.
Research Focus
The Tremethick research group focuses on understanding the intricate mechanisms of chromatin structure and function. They investigate how the local ‘nucleosome beads-on-a-string’ structure of chromatin folds into larger, spatially organized 3D structures and the crucial role that histone variants play in this process. Additionally, they explore how these histone variants regulate RNA processing, with particular attention to their implications for brain function and cancer. The group is also keen on uncovering how the epigenome co-ordinately regulates global patterns of gene expression to control cell function, aiming to elucidate the broader implications for cellular behavior and disease.
Short Bio
After pursuing Chemistry studies in Germany and the UK and earned his Ph.D. in 1995 from the University of Newcastle upon Tyne. Following seven years at EMBL, he joined the Victor Chang Institute in Sydney in 2002. He held roles at UNSW and became a Professor of RNA Biology at ANU in 2011. In 2020, he became the director of ANU Shine-Dalgarno Centre for RNA Innovation.
Potential Research Topics
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